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KMID : 0603820080140020127
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Journal of Experimental & Biomedical Science
2008 Volume.14 No. 2 p.127 ~ p.130
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Analysis of Tandem Repeats in the Promoter Region of iNOS Gene in Korean Genome
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Kim Sun-Ji
Yoo Min
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Abstract
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To investigate if there are tandem repeats in iNOS gene in Korean genome we applied PCR amplification followed by DNA sequencing. Tandem repeats we were looking at were (AAAT)n in the promoter region. Totally, 65 people were subjected for this experiment. Twenty of them were patients with metabolic disease. Only was found in all of these Korean samples. This result was somewhat different trom the data for Caucasians and other Asian people. So, we assume this is specific VNTR (variable number of tandem repeat) in Korean which can be used for the purpose of diagnosis and for the differentiation of ethnic groups.
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KEYWORD
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iNOS, VNTR, Genetic diagnosis
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